METHOD FOR PREDICTION OF SEVERE PREECLAMPSIA Russian patent published in 2020 - IPC A61B5/00 G01N33/487 G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics, and can be used for prediction of severe preeclampsia. Anamnestic parameters are collected and blood is analyzed. Data collection is carried out in the first trimester of pregnancy, presence of heredity weighed down by cardiovascular pathology is determined, presence of anemia is determined, creatinine, AST, PAPP-A values are evaluated, APTT and INR are determined by coagulogram. A prognostic index PI_PE is calculated by formula: PI_PE= -2.42X₁-3.17X₂+1.48X₃+0.1X₄-0.1X₅-7.35X₆+1.93X₇-32.3, where PI_PE is a prognostic index of developing severe preeclampsia; X₁ - presence of anemia (1 - the patient has anemia (hemoglobin in 1 trimester <110 g/l), 0 - no anemia); X₂ - heredity, burdened by cardiovascular pathology (1 - burdened heredity, 0 - non-aggravated heredity); X₃ - level of APTT in 1 trimester, s; X₄ - level of AST in 1 trimester, unit/l; X₅ - level of creatinine in 1 trimester, mcmol/l; X₆ - INR in 1 trimester, conv. units; X₇ - level of PAPP-A in 11-13.6 weeks, MoM; Constant = - 32.3. If PI_PE>0, the low risk of developing severe preeclampsia is predicted, while the PI_PE≤0 high risk of developing severe preeclampsia is stated.

EFFECT: method enables predicting severe preeclampsia (early or late) with a high degree of reliability ensured by an integrated assessment of the following: anamnesis data, biochemical blood analysis and analysis of coagulogram of pregnant women with subsequent calculation of prognostic index.

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