METHOD FOR PREDICTION OF INCIDENCE OF EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Russian patent published in 2024 - IPC G01N33/68 G01N33/573 A61B5/08 A61B10/00 

Abstract RU 2822081 C1

FIELD: medicine.

SUBSTANCE: invention relates to therapy and pulmonology, and can be used to predict the incidence of exacerbations of chronic obstructive pulmonary disease (COPD) based on blood plasma laboratory values. Level of C-reactive protein and fractalkine is determined by enzyme immunoassay combined with establishing the COPD phenotype: emphysematous, mixed, bronchitic or phenotype of bronchial asthma with COPD (BA + COPD), presence of pneumococcal vaccination. Probability of frequent exacerbations of COPD is calculated by formula

where p is the probability of frequent exacerbations of COPD - 2–3 times a year in fractions of a unit; e is Euler's number (constant) equal to 2.71828; z = −3.434 + 0.501 × CRP + 2.389 × Emph PH + 2.311×C×Br PH−4.395×CX3CL1−2.927×PV; where −3.434 is a constant; 0.501 is the coefficient of the first variable; CRP is the level of C-reactive protein, mg/l; in case of BA + COPD phenotype in patient: Emph PH is equal to 0, Mix PH is equal to 0, Br PH is equal to 0; 2.389 is the coefficient of the second variable; Emph PH is emphysematous phenotype of COPD, in case of presence of this phenotype in patient: Emph PH is equal to 1, Mix PH is equal to 0, Br PH is equal to 0; 2.311 is the coefficient of the third variable; Mix PH is mixed COPD phenotype, if the patient has this phenotype: Mix PH is equal to 1, Emph PH is equal to 0, Br PH is equal to 0; 3.663 is the coefficient of the fourth variable; Br PH is bronchitic phenotype of COPD, in case of presence of this phenotype in patient: Br PH is equal to 1, Emph PH is equal to 0, Mix PH is equal to 0; −4.395 is the coefficient of the fifth variable; CX3CL1 is fractalkine level, ng/ml; −2.927 is the coefficient of the sixth variable; PV - pneumococcal vaccination: 0 – absence, 1 – presence. If p is less than 0.5, a low risk of frequent exacerbations of COPD is predicted. If p is more than or equal to 0.5, a high risk of frequent exacerbations of COPD is predicted.

EFFECT: method enables to predict the rate of development of exacerbations in patients with different phenotypes of COPD due to: determining blood C-reactive protein and fractalkine, establishing the COPD phenotype and the presence of pneumococcal vaccination.

1 cl, 4 ex

Similar patents RU2822081C1

Title Year Author Number
METHOD FOR PREDICTION OF RISK OF DEVELOPING LIFE THREATENING COMPLICATIONS IN PATIENTS WITH MYOCARDIAL INFARCTION WITH BACKGROUND OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2019
  • Polunina Olga Sergeevna
  • Kuzmichev Bogdan Yurevich
  • Voronina Lyudmila Petrovna
  • Sevostyanova Irina Viktorovna
  • Polunina Ekaterina Andreevna
  • Kuzmichev Kirill Yurevich
  • Prokofeva Tatyana Vasilevna
RU2740896C1
METHOD FOR PREDICTION OF EFFECTIVE TREATMENT WITH ROFLUMILAST OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE PHENOTYPE "WITH FREQUENT EXACERBATIONS" 2019
  • Kulik Ekaterina Gennadevna
  • Pavlenko Valentina Ivanovna
  • Naryshkina Svetlana Vladimirovna
RU2712244C1
METHOD OF ACTIVATING FACTORS OF ANTIVIRAL PROTECTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2015
  • Protasov Andrej Dmitrievich
  • Kostinov Mikhail Petrovich
RU2591809C1
METHOD FOR FORMING IMMUNOLOGICAL MEMORY TO STREPTOCOCCUS PNEUMONIAE ANTIGENS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2014
  • Protasov Andrej Dmitrievich
  • Zhestkov Aleksandr Viktorovich
  • Kostinov Mikhail Petrovich
  • Zolotarev Pavel Nikolaevich
  • Tezikov Jurij Vladimirovich
RU2544168C1
METHOD FOR PREDICTING RISK OF DEVELOPMENT OF ISCHEMIC HEART DISEASE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2015
  • Uklistaya Tatyana Aronovna
  • Polunina Olga Sergeevna
  • Sevostyanova Irina Viktorovna
  • Uklistaya Elena Aronovna
  • Polunina Ekaterina Andreevna
RU2620545C1
METHOD FOR PREDICTING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PERSONS WORKING UNDER EXPOSURE TO INDUSTRIAL AEROSOLS 2021
  • Shpagina Lyubov Anatolevna
  • Kotova Olga Sergeevna
  • Karmanovskaya Svetlana Aleksandrovna
  • Shpagin Ilya Semenovich
  • Kamneva Natalya Vadimovna
  • Anikina Ekaterina Valentinovna
  • Gerasimenko Dmitrij Alekseevich
  • Lisova Evgeniya Sergeevna
RU2774206C1
METHOD FOR PREDICTION EFFICACY OF GLUCOCORTICOID THERAPY IN PATIENTS WITH AGGRAVATED CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2011
  • Tsejmakh Irina Jakovlevna
  • Khabarov Aleksej Stanislavovich
  • Kostjuchenko Gennadij Ivanovich
RU2490645C2
METHOD OF ENHANCING NONSPECIFIC PROTECTION FACTORS ACTIVITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2015
  • Protasov Andrej Dmitrievich
  • Kostinov Mikhail Petrovich
RU2600838C1
METHOD FOR PREDICTING RECRUDESCENCE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH INSOMNIA 2018
  • Budnevskij Andrej Valerievich
  • Kozhevnikova Svetlana Alekseevna
  • Goncharenko Olga Vladimirovna
  • Ovsyannikov Evgenij Sergeevich
  • Prozorova Galina Garaldovna
  • Fateeva Oksana Valerevna
  • Belov Vladislav Nikolaevich
RU2681272C1
METHOD FOR PREDICTING THE FREQUENCY OF EXACERBATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2016
  • Ogorodova Lyudmila Mikhajlovna
  • Saltykova Irina Vladimirovna
  • Sazonov Aleksej Eduardovich
  • Dorofeeva Yuliya Borisovna
  • Tyakht Aleksandr Viktorovich
  • Kirillova Natalya Aleksandrovna
  • Petrov Vyacheslav Alekseevich
  • Fedosenko Sergej Vyacheslavovich
RU2657788C1

RU 2 822 081 C1

Authors

Orlova Ekaterina Alekseevna

Kuzmichev Bogdan Yurevich

Dorfman Inna Petrovna

Orlov Maksim Mikhajlovich

Panova Vera Vladimirovna

Dates

2024-07-01Published

2023-04-04Filed