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(19)

(11)

2 823 305

(13)

(51)

IPC

C12N1/21(2006-01-01)

C12N15/77(2006-01-01)

C12P19/26(2006-01-01)

C12R1/15(2006-01-01)

(21) (22)

Application

2022110751, 2019-12-17

(24)

Start date

2019-12-17

(22)

Actual filing date

2019-12-17

(45)

Published

2024-07-22

(72)

Inventor

Kan, ChzhenChen, TszyanKhu, LitaoDu, GuochenVan, YanLi, TszyankhuaLi, TszyalyanChzhan, Tyanmen

(73)

Holder

Blumejdzh Bioteknolodzhi Korporejshn LimitedTszyannan Yuniversiti

RECOMBINANT CORYNEBACTERIUM GLUTAMICUM FOR EFFICIENT SYNTHESIS OF HIGHLY PURE HYALURONIC ACID AND OLIGOSACCHARIDES THEREOF Russian patent published in 2024 - IPC C12N1/21 C12N15/77 C12P19/26 C12R1/15

Abstract RU 2823305 C1

FIELD: biotechnology.

SUBSTANCE: disclosed is a recombinant bacterium Corynebacterium glutamicum for producing hyaluronic acid, comprising switched off or knocked out exopolysaccharide genes cg0420 and/or cg0424, wherein said bacterium contains a gene coding hyaluronate synthase, and a gene coding hemoglobin VHb. Also disclosed is a method of constructing said recombinant bacteria, a method of producing hyaluronic acid using said recombinant bacteria.

EFFECT: invention provides production of hyaluronic acid with increased output and purity.

8 cl, 5 dwg, 3 ex

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RU 2 823 305 C1

Authors

Kan, Chzhen

Chen, Tszyan

Khu, Litao

Du, Guochen

Van, Yan

Li, Tszyankhua

Li, Tszyalyan

Chzhan, Tyanmen

Dates

2024-07-22—Published

2019-12-17—Filed