METHOD OF PRODUCING AMORPHOUS SOLID DISPERSION OF N-BUTYL-N-METHYL-1-PHENYLPYRROLO[1,2-A]PYRAZINE-3-CARBOXAMIDE Russian patent published in 2024 - IPC C07D487/04 A61K31/4985 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing an amorphous solid dispersion containing a pharmaceutical substance as an active substance N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide, and as a polymer, additives are acceptable in pharmaceutical technology, according to which mixture containing 1 g of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide, polyvinylpyrrolidone polymer (15–20 g) or PEG 6000/vinylcaprolactam/vinyl acetate (15–20 g), at a weight ratio of 1:15–20, is dissolved in 34–96% ethanol (30–35 g), the obtained solution is dried at 40–65°C in a drying cabinet for 8–12 hours.

EFFECT: novel method of producing an amorphous solid dispersion containing a pharmaceutical substance as an active substance N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide, which enables to obtain N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide from a crystalline into an amorphous state and improve the solubility and pharmaceutical bioavailability of tablets based thereon.

1 cl, 6 dwg, 2 tbl, 9 ex