FIELD: medicine; pharmacy.
SUBSTANCE: invention discloses a pharmaceutical composition in the form of a solid dosage form with anxiolytic and antidepressant activity, containing N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazin-3- carboxamide and the following excipients: filler — lactose and microcrystalline cellulose, disintegrant — cross-linked polyvinylpyrrolidone (crospovidone) and/or croscarmellose sodium or sodium starch glycolate, binder — polyvinylpyrrolidone with a molecular weight of 28,000–34,000 or hydroxypropyl methylcellulose with substitution type 2910 or co polyvinyl alcohol polymer and polyethylene glycol and sliding agent — magnesium stearate in the following ratio, wt.%: N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide 0.05–5.0; filler 64.00–95.95; disintegrant 2.00–10.00; binder 1.50–20.00; sliding agent 0.50–1.00.
EFFECT: expanding the arsenal of medicinal products with anxiolytic and antidepressant effects and improving the technological characteristics of a pharmaceutical composition based on N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (flowability, bulk density, compressibility and disintegration) compared to the substance.
2 cl, 8 tbl, 13 ex
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