METHOD OF PRODUCING TABLETS OF N-BUTYL-N-METHYL-1-PHENYLPYRROLO[1,2-a]PYRAZINE-3-CARBOXAMIDE Russian patent published in 2024 - IPC A61K9/20 A61K31/4985 A61P25/22 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a method of producing tablets of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide. Method of producing tabletted form of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide by wet granulation, where N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide weighing 1 mg and polyvinylpyrrolidone weighing 15 mg are dissolved in 14–59 mg of an aqueous-alcoholic or alcohol solution containing 34–96 % ethyl alcohol, then the obtained solution is moistened with a mixture of pre-sieved auxiliary substances: lactose 45 mg, microcrystalline cellulose 30 mg, cross-linked polyvinylpyrrolidone 4 mg, croscarmellose sodium 4 mg, after which the obtained mixture is punched through a sieve with diameter of 2 mm using a granulator, dried in a drying cabinet at temperature of 40–65 °C for 8–12 hours, then repeatedly punched through a sieve, obtained granules are powdered with magnesium stearate 1 mg, followed by pressing into tablets weighing 100 mg.

EFFECT: disclosed is a method of producing tablets of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide.

1 cl, 2 tbl, 4 ex