FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing a compound of formula III. Proposed method includes: a) adding a Grignard reagent to a mixture containing a compound of formula II, toluene and tetrahydrofuran at 60 °C or lower; and b) adding the obtained mixture to a mixture containing acetyl chloride and ethyl acetate at 20 °C or lower. Also disclosed are methods of producing compounds of formula XI, formula IX, formula VII, formula V and formula IV.
EFFECT: invention enables to provide a method for synthesis of a compound of formula III, which is suitable for preparing a compound of formula XI (lemborexant) containing a small amount of impurities.
10 cl, 3 ex, 2 tbl
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