METHOD OF PRODUCING BIOCOMPOSITE WITH ANTIBACTERIAL PROPERTIES Russian patent published in 2024 - IPC A61K6/00 A61L27/10 A61L27/12 A61L27/20 A61L27/54 C04B35/16 C04B35/447 

FIELD: medicine.

SUBSTANCE: invention relates to a method of producing bioresorbable osteoplastic dispersed biocomposites of synthetic type, intended for treating diseases and injuries of the human bone system, and can be used in dentistry and maxillofacial surgery. Proposed method of producing a biocomposite with antibacterial properties based on wollastonite and hydroxyapatite involves preparing a reaction mixture, containing precursors—sodium metasilicate, calcium chloride, ammonium hydrophosphate and ammonium hydroxide in the form of aqueous solutions, in the form of a colloidal solution. Said colloidal solution is placed in an autoclave, heated until temperature reaches 180 °C, and held at said temperature for 6 hours. Obtained biocomposite in the form of an amorphous precipitate is separated, washed, dried and calcined at a heating rate of 10 °C/min until temperature reaches 800 °C, held at the achieved maximum temperature for 60 minutes. Obtained biocomposite of the crystalline composition is treated with a chitosan solution containing silver ions, after which the treated biocomposite is separated and dried in air at temperature of 20–25 °C for 1 hour. For the preparation of a chitosan solution containing silver ions, chitosan is dissolved in acetic acid, stirred at rate of 300 rpm for 6 hours, silver nitrate powder is added at a ratio of chitosan: acetic acid: silver nitrate powder of 0.4 g: 40 ml: 0.9 g, respectively, and the obtained mixture is boiled at 100 °C for 2 hours.

EFFECT: simpler technology compared to the prototype by reducing the amount of reagents requiring more thorough burning from the volume of the biocomposite; obtaining a biocomposite having biocompatible and antibacterial properties.

3 cl, 2 tbl, 3 ex, 7 dwg