METHODS OF TREATING SYMPTOMS AND DISORDERS ASSOCIATED WITH LYSOSOMAL STORAGE DISEASES Russian patent published in 2024 - IPC A61K31/439 A61P25/00 A61P25/28 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to chemistry and pharmaceutical industry, namely to a method of treating or preventing cognitive dysfunction associated with lysosomal storage disease in a human subject in need thereof. Disclosed method involves administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) has the structure , wherein: R¹ is hydrogen; R² and R³ are independently selected from C_1-3-alkyl; R⁴, R⁵ and R⁶ are independently selected from hydrogen and halogen; A is thiazolyl.

EFFECT: invention provides a method which is effective for improving cognitive abilities or reducing cognitive deficits, as measured by a reduction in the time required to complete the route building test (TMT), TMT-A and/or TMT-B, reducing the difference between time TMT-A and time TMT-B (TMT-A - TMT-B).

16 cl, 2 dwg, 20 tbl, 7 ex