METHODS OF TREATING SYMPTOMS AND DISORDERS ASSOCIATED WITH LYSOSOMAL STORAGE DISEASES Russian patent published in 2024 - IPC A61K31/16 A61K31/165 A61K31/21 A61K31/33 A61K31/395 A61K31/435 A61K31/439 A61P3/06 A61P17/00 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to a method of treating or preventing pain. Method of treating or preventing pain in a human subject in need thereof, where the person has Fabry disease and where the pain is selected from neuropathic pain, gastrointestinal pain and peripheral neuropathy, comprising administering to a subject an effective amount of a compound of formula (I)

or a pharmaceutically acceptable salt or prodrug thereof, where R¹ is selected from hydrogen, halogen, cyano, nitro, hydroxy, thio, amino, C_1-6-alkyl, C₂-₆-alkenyl, C_1-6-alkyloxy, C_2-6-alkenyloxy and C_2-6-alkynyloxy, where said alkyl, alkenyl, alkynyl, alkyloxy, alkenyloxy or alkynyloxy is optionally substituted with one or more groups selected from halogen, cyano, nitro, hydroxy, thio or amino; R² and R³ are independently selected from C_1-3-alkyl, optionally substituted with one or more halogens, or R² and R³ together form a cyclopropyl or cyclobutyl group, optionally substituted with one or more halogens; R⁴, R⁵ and R⁶ are each independently selected from hydrogen, halogen, nitro, hydroxy, thio, amino, C_1-6-alkyl and C_1-6-alkyloxy, where said alkyl or alkyloxy is optionally substituted with one or more in groups, selected from halogen, hydroxy, cyano and C_1-6-alkyloxy; and A is 5- or 6-membered aryl or heteroaryl group, optionally substituted with 1, 2 or 3 groups, independently selected from halogen, hydroxy, thio, amino, nitro, C_1-6-alkoxy or C_1-6-alkyl.

EFFECT: use of the invention provides the treatment or prevention of pain, including neuropathic pain, gastrointestinal pain and peripheral neuropathy, in a human subject in need thereof, where the person has Fabry disease.

15 cl, 19 tbl, 7 ex