METHOD FOR MODELING ALCOHOL-INDUCED NEPHROPATHY AGAINST THE BACKGROUND OF AUTOIMMUNE NEPHRITIS IN RATS IN AN EXPERIMENT Russian patent published in 2022 - IPC G09B23/28 A61D7/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, experimental biology, toxicology. The method for modeling alcohol-induced nephropathy against the background of autoimmune nephritis in rats in the experiment includes a single subcutaneous injection to experimental animals in five points: in the axillary and inguinal areas and intraperitoneal solution of a complete Freund adjuvant with an equal volume of a mixture of homogenate of the cortex of the kidney, previously diluted with normal saline, based on 100.0 mg of tissue 1.0 ml of saline 0.1 ml the active solution per 100 g of animal weight. Then, for 30 days, a 40% ethanol solution at a dose of 3 g/kg is intragastrically administered for 30 days, and at the same time an alcohol dehydrogenase inhibitor, an isovaleric acid amide solution, at a dose of 500 mg/kg of animal weight, where 50 mg of isovaleric acid amide is accounted for per 0.9 ml solution unit.

EFFECT: method provides an increase in reproducibility, is convenient for carrying out on animals and is economically profitable.

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