KERATIN BD-4, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF Russian patent published in 2024 - IPC C07K14/47 C12P21/02 A61K38/17 A61P11/00 A61P25/08 A61P29/00 

Abstract RU 2824893 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to versions of keratin and can be used in medicine in the manufacture of a medicinal agent for antipyretic therapy, analgesic therapy, antitussive therapy, expectorant therapy, anticonvulsant therapy or antiepileptic therapy.

EFFECT: invention provides the therapeutic use of keratin, having efficacy in suppressing an increase in body temperature in a fever model in SD rats and prolonging the incubation period of class II and class III epilepsy in mice; expectorant action in a method for excretion of phenol red in mice; antitussive action in the method for stimulating cough with the help of ammonia water in mice, a tendency to reduce the number of writhings in mice and analgesic action in acetic acid-induced writhings in ICR mice.

8 cl, 3 dwg, 9 tbl, 14 ex

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RU 2 824 893 C1

Authors

Yu Shishan

Wang Xiaoliang

Qu Jing

Li Mi

Su Guozhu

Wang Ling

Cai Jie

Xu Shaofeng

Fu Jiang

Dates

2024-08-15Published

2020-10-28Filed