CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE- OR ALKYNE-PHOSPHONOTHIOLATES AND -PHOSPHONATES Russian patent published in 2024 - IPC C07K16/28 A61K47/68 C07F9/40 

Abstract RU 2825582 C2

FIELD: biotechnology.

SUBSTANCE: described is a group of inventions involving a method of producing a phosphonothiolate (embodiments), a method of producing a compound of formula (I) or formula (I*), a compound (embodiments), a solid-phase peptide synthesis kit. In one embodiment, the method of producing a phosphonothiolate involves a step for reacting a compound of formula (I) with a thiol-containing molecule to obtain a compound of formula (III).

EFFECT: invention widens the range of methods for producing phosphonothiolates.

22 cl, 22 dwg, 5 tbl, 25 ex

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RU 2 825 582 C2

Authors

Khakenberger, Kristian

Baumann, Elis Leoni

Kasper, Mark-Andre

Birn, Stiven

Khelma-Smets, Jonas

Leonkhardt, Genrikh

Stoshek, Tina

Gerlakh, Markus

Shumakher, Dominik

Dates

2024-08-27Published

2019-03-06Filed