STABLE CONCENTRATED RADIOPHARMACEUTICAL COMPOSITION Russian patent published in 2025 - IPC A61K51/08 A61K47/12 A61K47/22 A61P35/00 

Abstract RU 2839656 C1

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions refers to pharmaceutics, namely to radiopharmaceutical compositions, and can be used for treating cancer. Pharmaceutical composition contains: (a) a complex formed by radionuclide 177Lu and NeoB of formula (I) and (b) at least two stabilizers preventing radiolytic decomposition, where said stabilizers contain gentisic acid and ascorbic acid in a weight ratio of 1:16 to 1:10. Said radionuclide is present in concentration providing volumetric radioactivity of at least 370 MBq/ml (at the end of processing) ±37 MBq/ml (±10%). Embodiments of said composition are also disclosed.

EFFECT: obtained compositions are characterized by a high concentration of a radionuclide complex which is chemically and radiochemically very stable.

9 cl, 10 tbl, 4 ex

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RU 2 839 656 C1

Authors

Mariani, Maurizio F.

Orlandi, Francesca

Fugazza, Lorenza

Sacchetti, Lorenzo

Tedesco, Mattia

Barbato, Donato

Dates

2025-05-07Published

2020-09-15Filed