FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions refers to pharmaceutics, namely to radiopharmaceutical compositions, and can be used for treating cancer. Pharmaceutical composition contains: (a) a complex formed by radionuclide 177Lu and NeoB of formula (I) and (b) at least two stabilizers preventing radiolytic decomposition, where said stabilizers contain gentisic acid and ascorbic acid in a weight ratio of 1:16 to 1:10. Said radionuclide is present in concentration providing volumetric radioactivity of at least 370 MBq/ml (at the end of processing) ±37 MBq/ml (±10%). Embodiments of said composition are also disclosed.
EFFECT: obtained compositions are characterized by a high concentration of a radionuclide complex which is chemically and radiochemically very stable.
9 cl, 10 tbl, 4 ex
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Authors
Dates
2025-05-07—Published
2020-09-15—Filed