METHOD FOR DETERMINING THRESHOLD SENSITIVITY OF OLFACTORY ANALYSER USING OBJECTIVE OLFACTOMETRY Russian patent published in 2024 - IPC A61B5/08 A61B5/381 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to otorhinolaryngology. Method for determining threshold sensitivity of the olfactory analyser is carried out by objective olfactometry using an olfactometer connected to an electroencephalography module by recording olfactory evoked potentials (OEP) and chemosensory evoked potentials (CEP). For recording olfactory evoked potentials, phenylethyl alcohol is used in concentration of 30%, 40%, 50%, and for recording chemosensory evoked potentials – carbon dioxide in concentration selected individually so that tingling of the mucous membrane is felt in the nasal cavity: 30%, 35%, 40%. Air and odorants are supplied alternately, intranasally through a cannula located outside the nasal valve. To the outlet hole of the olfactometer two air flows are supplied, which have the same flow rate of 8 l/min, temperature and humidity of 80%. During interval of 40 s between stimulations, air containing an odour is aspirated, and odourless air is supplied into the nose. Evoked potentials are recorded only at the moment of the odorant delivery; the stimulus duration is equal to 200 ms. Electroencephalography unit is coupled with the respiratory centre, and the odorant is ejected and the electroencephalogram is recorded immediately after inhalation. 60 repetitions of one stimulus are recorded; after each 15th repetition, half of the nose is changed.

EFFECT: possibility of determining the threshold of the olfactory analyser individually for each person being tested, improving the accuracy of determining the threshold sensitivity of the olfactory analyser in the patients with normosmia and olfactory disorder, thereby detecting reversibility of the olfactory disorder process, and selecting a therapeutic approach.

1 cl, 8 dwg