METHODS OF TREATING HIV-1 INFECTION Russian patent published in 2024 - IPC A61K31/415 A61K31/513 A61K31/536 A61K31/675 A61P31/18 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to treating HIV-1 infection and increasing the number of activated T cells in a subject. Method of treating HIV-1 infection and increasing the number of activated T cells in a subject, comprising administering to a subject in need thereof a combination comprising a) efavirenz, emtricitabine and tenofovir DF and b) N-carbamimidoyl-5-(1-methylpyrazol-4-yl)naphthalene-2-carboxamide or a pharmaceutically acceptable salt thereof. Application of a) efavirenz, emtricitabine and tenofovir DF and b) N-carbamimidoyl-5-(1-methylpyrazol-4-yl)naphthalene-2-carboxamide or a pharmaceutically acceptable salt thereof for preparing a medicament for treating HIV-1 infection and increasing the number of activated T cells in a subject.

EFFECT: method and use described above provide an effective treatment of HIV-1 infection and an increase in the number of activated T cells in a subject, CD4⁺ and CD8⁺ T-cell function is improved by adding B1T225 to Atripla containing efavirenz, emtricitabine and tenofovir DF, as well as reducing the level of sCD163 in plasma.

20 cl, 9 dwg, 3 ex