FIELD: biotechnology; medicine.
SUBSTANCE: invention relates to biotechnology, immunology and medicine. Disclosed are populations of pluripotent and endocrine cells, as well as pancreatic endoderm cells, which do not express cell surface proteins of one or more MHC class I, and expression of at least one ligand activating NK cells is disturbed or inhibited.
EFFECT: cell populations of the present invention can be used to reduce insulin dependence and/or reduce hypoglycaemia in patients with diabetes.
30 cl, 15 dwg, 3 tbl, 17 ex
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