FIELD: biotechnology.
SUBSTANCE: group of inventions relates to an isolated mesenchymal stem cell, a cell composition based thereon and use thereof. Isolated mesenchymal stem cell (MSC), obtained from blood, preferably peripheral blood, when measured is positive for mesenchymal markers CD29, CD44 and CD90 and negative for MHC class II molecules, wherein said MSC when co-cultured with peripheral blood mononuclear cells (PBMC) and compared to MSC having the same characteristics, but not co-cultured with PBMC, secretes immunomodulatory cytokine prostaglandin E2 (PgE2), characterized by increased secretion of IL-6 and IL-10 and inhibits secretion of TNF-α and IFN-γ PBMC cells. Cell composition containing at least 60% of said recovered MSC, where at least 95% of said cells are single cells, is suitable for treating immune-related diseases and/or inflammatory processes in a subject.
EFFECT: inventions provide immunomodulatory MSC with high therapeutic safety and efficacy.
10 cl, 5 dwg, 4 ex
