FIELD: biotechnology.
SUBSTANCE: group of inventions relates to an isolated mesenchymal stem cell, a cell composition based thereon and use thereof. Isolated mesenchymal stem cell (MSC), obtained from blood, preferably peripheral blood, when measured is positive for mesenchymal markers CD29, CD44 and CD90 and negative for MHC class II molecules, wherein said MSC when co-cultured with peripheral blood mononuclear cells (PBMC) and compared to MSC having the same characteristics, but not co-cultured with PBMC, secretes immunomodulatory cytokine prostaglandin E2 (PgE2), characterized by increased secretion of IL-6 and IL-10 and inhibits secretion of TNF-α and IFN-γ PBMC cells. Cell composition containing at least 60% of said recovered MSC, where at least 95% of said cells are single cells, is suitable for treating immune-related diseases and/or inflammatory processes in a subject.
EFFECT: inventions provide immunomodulatory MSC with high therapeutic safety and efficacy.
10 cl, 5 dwg, 4 ex
| Title |
Year |
Author |
Number |
| METHODS AND COMPOSITIONS FOR USE IN CELL THERAPY |
2010 |
- Lombardo Eleuterio
- Busher Dirk
|
RU2610427C2 |
| METHOD OF CELL EXPANSION, METHOD OF OBTAINING CONDITIONED MEDIUM, POPULATION OF ADHESIVE MESENCHYMAL STROMAL CELLS OF PLACENTA OR ADIPOSE TISSUE, PHARMACEUTICAL COMPOSITION AND APPLICATION OF ADHESIVE MESENCHYMAL STROMAL CELLS OF PLACENTA OR ADIPOSE TISSUE IN TRANSPLANTATION |
2007 |
- Meretski Shaj
- Aberman Zami
- Bjurger Ora
|
RU2433177C2 |
| INDUCTION MEDIUM AND METHODS OF STEM CELL CULTIVATION AND THERAPY |
2015 |
|
RU2717983C2 |
| Tr1 CELLS, MESENCHYMAL STEM CELLS AND USING THEM |
2008 |
- Fussa Arno
- Bel'Mont Natali
|
RU2493869C2 |
| COMPOSITION FOR PREVENTING OR TREATING OSTEOARTHRITIS CONTAINING MESENCHYMAL STEM CELLS EXPRESSING GENE 6 INDUCED BY TUMOUR NECROSIS FACTOR |
2021 |
- Ryu, Je Young
- Nam, Seung Woo
- Kim, Chang Young
- Kim, Donghoon
- Shin, Jung Youn
|
RU2822798C1 |
| MESENCHYMAL STROMAL CELLS FOR TREATING SEPSIS |
2015 |
- Dalemans, Wilfried
- Lombardo, Eleuterio
- Dekker, Robert
|
RU2715866C2 |
| METHOD FOR OBTAINING CELLS FROM DENTAL PULP |
2019 |
- Imagawa, Kiwamu
- Minami, Kotaro
- Maeda, Kenichi
- Hosoda, Yuki
- Watanabe, Shunsuke
- Sato, Kazutoshi
- Higashiguchi, Yasuna
- Kushida, Takashi
- Ishiwari, Ayumi
|
RU2795621C2 |
| PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES MEDIATED BY REGULATORY T-CELLS |
2017 |
- Son, Sun Uk
- Li, Tak Gi
- Li, Khen Chu
|
RU2727900C2 |
| EXTRACELLULAR VESICLES ORIGINATING FROM MESENCHYMAL STEM CELLS |
2019 |
- De Frantsisko, Anzhelita
- Khan, Chzhunchao
|
RU2805066C2 |
| HUTC MODULATION OF PRO-INFLAMMATORY MEDIATORS OF LUNG AND PULMONARY DISEASES AND DISORDERS |
2013 |
|
RU2668389C2 |
