METHOD FOR PREDICTING DEVELOPMENT OF COGNITIVE DISORDERS IN PATIENTS WITH PARKINSON'S DISEASE Russian patent published in 2024 - IPC A61B5/55 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to neurology, and can be used to predict the development of cognitive disorders in patients with Parkinson's disease (PD). Magnetic resonance imaging (MRI) of the brain is performed at rest and the area of the substantia nigra is determined. PCR is carried out in real time and genetic parameter RS12 is determined by rs12411216 variant. Patient is tested by MoCA-test and MDS-UPDRS. If the MoCA test diagnoses the absence of cognitive impairment, the P value is determined by formula P=1/(1+EXP(-Z)), where Z=-139.127-1.0896*A+568.7794*B+1.4316*C, A is an indicator of the third part of the MDS-UPDRS scale, B is the ratio of the difference in the area of the substantia nigra on the right and on the left to their sum, C is the genetic indicator RS12 by rs12411216 variant. At P≤0.995, predicts the development of cognitive disorders.

EFFECT: method provides the timely assessment of the probability of developing cognitive impairment in the patients with PD during the progression of the chronic neurodegenerative process by using specific clinical, molecular genetic and neuroimaging markers as predictors.

1 cl, 5 dwg, 3 ex