METHOD FOR DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE AND DIFFUSE LEWY BODY DISEASE Russian patent published in 2025 - IPC G01N33/68 G01N33/573 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neurology, laboratory diagnostics, and can be used for differential diagnosis of Parkinson's disease and diffuse Lewy body disease (DLBD). Blood is sampled to determine laboratory data. Heat shock proteins 70 (HSP 70), ng/ml, are measured in patient’s blood by enzyme-linked immunosorbent assay. If HSP 70 value is less than or equal to 4.9 ng/ml, the absence of Parkinson's disease and DLBD is diagnosed. If its value is from 4.91 to 21.9 ng/ml, Parkinson's disease is diagnosed. If the value is more than 21.9 ng/ml, diffuse Lewy body disease is diagnosed.

EFFECT: method provides the possibility of increasing the accuracy of the differential diagnosis of Parkinson's disease and DLBD, objectification and standardization, simplicity of implementation due to use of reliable laboratory criterion – determination of quantitative content of HSP 70 in patient’s peripheral blood serum by method of enzyme-linked immunosorbent assay.

1 cl, 4 ex