FIELD: immunology.
SUBSTANCE: disclosed is a chimeric antigen receptor (CAR) system which includes a receptor component comprising an antigen-binding domain, a transmembrane domain and a first binding domain; and also includes an intracellular signaling component comprising a CD3-zet endodomain and a second binding domain which specifically binds the first binding domain, wherein bonding of the first and second binding domains can be disturbed in the presence of a certain agent. Also presented is a CAR coding nucleic acid, an expression vector, T- and NK-cells, use thereof, method of producing T- or NK-cells and method of inhibiting CAR signaling system.
EFFECT: this group of inventions can be used in producing a drug for treating and/or preventing cancer diseases.
28 cl, 3 tbl, 4 ex, 14 dwg
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