PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION CONTAINING ENZALUTAMIDE Russian patent published in 2024 - IPC A61K31/4166 A61K47/02 A61K47/32 A61K9/20 A61P13/08 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutics, namely to a pharmaceutical composition for oral administration of enzalutamide and a method for preparing it. Pharmaceutical composition for oral administration of enzalutamide includes enzalutamide and polyvinyl alcohol, where polyvinyl alcohol has a degree of saponification from 63 mol.% to 85 mol.%, and a degree of polymerisation from 100 to 500, where the content of polyvinyl alcohol ranges from 50 wt.% to 500 wt.% with respect to the weight of enzalutamide, and further includes potassium chloride, sodium chloride or potassium dihydrophosphate as a co-disintegrant. Method of producing said pharmaceutical composition involves a step for preparing a solid dispersion containing enzalutamide and polyvinyl alcohol.

EFFECT: obtained pharmaceutical composition has improved solubility, increased bioavailability and rate of absorption of enzalutamide.

11 cl, 2 dwg, 28 tbl, 16 ex