SOLID ORAL NICOTINE FORMULATION Russian patent published in 2024 - IPC A61K31/465 A61K47/26 A61K47/38 A61K9/20 A61P25/34 

Abstract RU 2831119 C2

FIELD: smoking accessories.

SUBSTANCE: group of inventions relates to solid nicotine formulations for fast onset of nicotine craving relief. Compressed oral disintegrating nicotine tablet for rapid onset of nicotine craving, containing nicotine and a pH regulating agent, in which the tablet is intended to release the nicotine content for period of 60 seconds upon interaction with oral saliva and the tablet is intended to release the content of the pH regulating agent for period of 60 seconds when interacting with oral saliva, in which the tablet contains mannitol in an amount of more than 40 wt.% of the tablet, in which the tablet contains nicotine in amount of 0.5 to 10 mg, wherein the pH adjusting agent is an alkaline buffer agent, wherein the pH adjusting agent is selected from the group consisting of monocarbonate, bicarbonate, sesquicarbonate and any combination thereof, and in which the tablet contains a disintegrant in amount of 1–10 wt.% of the tablet, wherein the disintegrating agent is selected from a group consisting of crospovidone, croscarmellose sodium, sodium starch glycolate and any combination thereof. A method of relieving cravings for nicotine by administering an effective amount of said compressed oral disintegrating nicotine tablet.

EFFECT: above described nicotine tablet provides fast and effective onset of nicotine craving relief with reduction of burning sensation.

35 cl, 10 tbl, 7 ex

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RU 2 831 119 C2

Authors

Nielsen, Bruno Provstgaard

Nielsen, Kent Albin

Dates

2024-12-02Published

2018-12-07Filed