FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing functionally substituted 3,4,5,6,7,8-hexahydro-2H-pyrido[3,2-e][1,3]thiazines. Disclosed is a method of producing 5-aryl-4-thioxo-3,4,5,6-tetrahydro-2H-pyrido[3,2-e][1,3]thiazine-7(8H)-one of general formula 1, where R = aromatic substitute, which is selected from 2-C1C6H4, 4-MeOC6H4, 2-MeC6H4, 2-EtOC6H4, 2,5-(MeO)2C6H3 or 3,4,5-(MeO)3C6H2, involving reaction of 4-aryl-6-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolate of N-methylmorpholinium with hydrogen sulphide and then with excess aqueous solution of formaldehyde with short-term heating to boiling in a water-alcohol medium.
EFFECT: high output of the desired products, carrying out the reaction in the absence of strong acids, as well as introducing more readily available starting reagents into the reaction.
1 cl, 6 ex.
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