METHOD FOR DIAGNOSING CHRONIC BLEPHARITIS ASSOCIATED WITH HELICOBACTER PYLORI Russian patent published in 2024 - IPC G01N33/68 G01N33/497 G01N33/573 C12Q1/58 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to ophthalmology, gastroenterology, therapy, and can be used for diagnosing chronic blepharitis associated with Helicobacter pylori (H. pylori). A 13-C urease test is carried out and the following values are determined in the eye affected with blepharitis by enzyme-linked immunosorbent assay in a sample of lachrymal fluid: IgG to H. pylori, units/ml; total antibodies: IgA, IgM, IgG to CagA H. pylori antigen; interleukin 8 (IL 8), pg/ml; MCP-1, pg/ml. If observing a positive result of 13-C urease test and at least one of the lachrymal fluid values in the affected eye: positive values of IgG to H. pylori, positive values of total antibodies: IgA, IgM, IgG to CagA H. pylori antigen, IL 8 ≤ 5 pg/ml, MCP-1 > 400 pg/ml is used to diagnose chronic blepharitis associated with H. pylori.

EFFECT: method enables diagnosing blepharitis associated with Helicobacter pylori, based on a systematic approach, taking into account the relationship of clinical symptoms and biochemical parameters: 13-C urease test, IgG to Helicobacter pylori levels, total antibodies: IgA, IgM, IgG to CagA Helicobacter pylori antigen, IL 8 and MCP-1, with their subsequent analytical processing during patient examination.

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