FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to the pharmaceutical industry, in particular to the use of N'-benzylidene hydrazide 3β-O-acetyl-11-oxo-18βN-olean-12-en-30-oic acid as an agent inhibiting Zika virus.
EFFECT: invention enables high-efficiency inhibition of the cytopathic effect (CPE) of Zika virus in vitro, without having a toxic effect on SF268 cells (CC50 > 50 mcM).
1 cl, 5 dwg, 2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| USE OF CONJUGATES OF GLYCYRRHIZIC ACID WITH AMINO ACIDS AS INHIBITORS OF DENGUE 2 AND ZIKA FLAVIVIRUSES | 2020 |
|
RU2818911C2 |
| AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS | 2014 |
|
RU2568849C9 |
| METHOD OF PRODUCING CARBOXY-SUBSTITUTED GLYCOPEPTIDES OF GLYCYRRHIZIC ACID | 2014 |
|
RU2572785C1 |
| AGENT REPRESENTING 3-O-β-D-GLUCOPYRANOSYL-β-D-GLUCOPYRANOSIDE OLEAN-9( 11), 12( 13)-DIENE-30-ACID SHOWING ANTI-HIV-1 ACTIVITY, AND METHOD FOR PREPARING IT | 2011 |
|
RU2475246C2 |
| GLYCYRRHIZIC ACID GLYCOPEPTIDE WITH S-BENZYL-L-CYSTEINE ELICITING ANTI-HIV ACTIVITY | 2001 |
|
RU2198177C2 |
| METHOD OF PRODUCING MORONIC ACID | 2011 |
|
RU2472803C1 |
| CYTOTOXIC AND ANTIVIRAL ACTIVITY OF 3-ACYLOXYMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDS | 2018 |
|
RU2686100C1 |
| CYTOTOXIC AND ANTI-VIRAL ACTIVITY OF 3-ACYLOXIMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDES | 2018 |
|
RU2682669C1 |
| A-SECO-TRITERPENOIDS WITH METHYLKETONE FRAGMENT | 2013 |
|
RU2537840C1 |
| METHOD OF PRODUCING GLYCOPEPTIDES OF GLYCYRRHIZIC ACID | 2015 |
|
RU2615764C1 |
