INJECTION SOLUTION CONTAINING P-BORONOPHENYLALANINE Russian patent published in 2024 - IPC A61K9/08 A61K31/69 A61K47/02 A61K47/26 A61P35/00 

FIELD: chemistry; medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to chemistry, medicine and pharmaceutics, namely to an injection solution for boron-neutron capture therapy by intravenous drop injection and to a method of boron-neutron capture therapy. Proposed injection solution contains: 2.0–5.5 wt./vol.% of p-boronophenylalanine (or a pharmaceutically acceptable salt thereof) with a proportion of boron atoms-10 of boron atoms in compound of 75% or more; 2.0–7.0 wt./vol.% of sugar alcohol selected from sorbitol or mannitol; 0.01–0.6 wt./vol.% of antioxidant selected from sodium pyrosulphite, sodium sulphite or sodium bisulphite; citric acid for pH adjustment; water, wherein molar ratio of sugar alcohol and p-boronophenylalanine is (0.9–3.0):1.

EFFECT: group of inventions provides an injection solution effective for tumour reduction during boron-neutron capture therapy, which is stable both at low (5 °C ± 3 °C) and higher (40 °C) temperature.

4 cl, 1 dwg, 4 tbl, 72 ex