IMPLANTED PARTICLES AND RELATED METHODS Russian patent published in 2025 - IPC A61K9/50 A61K35/00 C08B37/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to an implantable hydrogel capsule for delivering a therapeutic agent to a subject, comprising: a) first compartment; b) a second compartment and c) a compound of formula (Ia)

or a pharmaceutically acceptable salt thereof, wherein the first and second compartments contain an alginate polymer; first compartment is surrounded by a second compartment; first compartment comprises a cell which produces a therapeutic agent; second compartment includes a compound of formula (I-a); capsule comprises an interface between a first and a second compartment, also relates to a pharmaceutically acceptable preparation based on a plurality of implanted hydrogel capsules, and also relates to a method of making an implantable hydrogel capsule, comprising bringing a plurality of drops of a polymer solution into contact with an aqueous solution for cross-linking for a period of time sufficient to obtain an implantable hydrogel capsule, where the cross-linking solution contains a cross-linking agent, a buffer and an osmolarity regulating agent.

EFFECT: group of inventions provides the development of particles made in the form of hydrogel millicapsules containing a first hydrogel compartment, a second hydrogel compartment and a compound of formula (I), which exhibit beneficial properties, for example, they are characterized by a higher level of antifibrous activity than similar millicapsules not containing compounds of formula (I), but consisting of a polymer of the same type and having essentially the same size, and they can also contain a larger number of cells, while having a minimum negative effect on the quality of the capsule compared to millicapsules containing one compartment.

31 cl, 61 dwg, 4 tbl, 22 ex