METHOD FOR PREDICTION OF CHRONIC PLACENTAL INSUFFICIENCY AFTER SUFFERING NEW CORONAVIRUS INFECTION (NCVI) OF MILD AND MODERATE FORM Russian patent published in 2025 - IPC A61B5/00 G01N33/49 G01N33/68 G01N33/86 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, and can be used for prediction of chronic placental insufficiency in pregnant women after suffering new coronavirus infection (NCVI) of mild and moderate form. Anamnestic data are examined: primiparous or multiparous, the presence or absence of obesity, the presence or absence of hypertension, the presence or absence of varicose veins of the lower extremities. Blood samples are taken at the moment of NCVI disease, in blood serum samples of patients are determined: thrombocyte, fibrinogen level, thrombin time, activated partial thromboplastin time, prothrombin index, international normalized ratio. Diagnostic index DI is calculated based on the assessment of anamnestic and laboratory data by formula: DI = 11.21 × x₁ + 11.16 × x₂ + 1.84 × x₃ + 3.58 × x₄ – 2.58 × x₅ – 2.23 × x₆ – 0.09 × x₇ + 4.79 × x₈ – 2.38 × x₉ + 1.11 × x₁₀ + 18.37 × x₁₁ – 12.63, where: x₁ – confirmed mild and moderate NCVI disease, 0 – disease in the first trimester – 5-12.6 weeks or in the third trimester – 28.0-42 weeks, 1 – disease in the second trimester – 13.0-27.6 weeks; x₂ – confirmed mild and moderate NCVI disease, 0 – disease in the first trimester – 5-12.6 weeks, in the second trimester – 13.0-27.6 weeks, 1 – disease in the third trimester – 28.0-42 weeks; x₃ – primiparous or multiparous, 0 – primiparous, 1 – multiparous; x₄ – obesity, 0 – no obesity, 1 – obesity; x₅ – hypertension, 0 – no hypertension, 1 – hypertension; x₆ – varicose veins of the lower extremities, 0 – no varicose veins of the lower extremities, 1 – there are varicose veins of the lower extremities; x₇ – thrombocyte level at the moment of NCVI disease, ×10⁹/l; x₈ – fibrinogen level at the moment of NCVI disease, g/l; x₉ – thrombin time at the moment of NCVI disease, sec; x₁₀ – activated partial thromboplastin time at the moment of NCVI disease, sec; x₁₁ – international normalized ratio at the moment of NCVI disease: clotting system index, which reflects the time required for formation of a complete fibrin clot after adding tissue thromboplastin and calcium to the test tube of the test sample, the result is compared with normalized blood clotting; -12.63 – a constant value. If DI is more than 0, developing chronic placental insufficiency is predicted. If DI is less than 0, the absence of chronic placental insufficiency is predicted.

EFFECT: method provides the possibility of predicting chronic placental insufficiency after suffering mild and moderate NCVI due to available methods of assessing anamnestic and laboratory data in order to optimize the management of this category of patients.

1 cl, 2 ex