FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a method for creating a cell model of drug-induced action on the pathogenesis of premature ovarian failure in rats. Said method is characterized by fact that 2 mcl/ml of omaveloxolone (RTA 408) is added to a cell culture of a cell model prepared by culturing granulosa cells of Wistar rat ovary and incubated for 1 hour.
EFFECT: present invention provides a cellular model of the drug-induced effect of omaveloxolone on the pathogenesis of premature ovarian failure.
1 cl, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CREATING CELL MODEL OF PREMATURE OVARIAN FAILURE IN WISTAR RATS | 2023 |
|
RU2815539C1 |
| ONE-STEP SURGICAL METHOD OF OVARIAN FUNCTION ACTIVATION FOR TREATMENT OF PREMATURE OVARIAN INSUFFICIENCY AND RESTORATION OF OVARIAL FUNCTION | 2020 |
|
RU2748246C1 |
| METHOD FOR MODELING POLYCYSTIC OVARIES AT PREDOMINANCE OF FOLLICULAR CYSTS | 2005 |
|
RU2282249C1 |
| 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE-METHYL, POLYMORPHOUS FORMS AND METHODS FOR USE THEREOF | 2014 |
|
RU2693833C2 |
| PROTEIN-PEPTIDE COMPLEX INCREASING THE VIABILITY OF FOLLICULES IN MAMMAL OVARIANS | 2017 |
|
RU2660587C1 |
| MEANS FOR CORRECTION OF OVARY DAMAGE CAUSED BY CYTOSTATIC EFFECT | 2021 |
|
RU2785397C1 |
| METHOD FOR DIAGNOSIS OF PREMATURE OVARIAN INSUFFICIENCY | 2020 |
|
RU2750159C1 |
| METHOD OF VITRIFICATION OF OVARIAL TISSUE | 2018 |
|
RU2678106C2 |
| METHOD FOR SIMULATING LYMPHOCYTE PEROXIDATION | 2013 |
|
RU2541771C2 |
| METHOD OF MODELLING OF POLYCYSTIC OVARIES | 2007 |
|
RU2337411C1 |
