FIELD: pharmaceutics.
SUBSTANCE: present invention relates to a method of producing a drug preparation for oral administration in the form of solid gelatinous capsules based on a self-emulsifying N-(adamant-2-yl)-N-(para-bromophenyl)amine delivery system, according to which 5-100 mg of N-(adamant-2-yl)-N-(para-bromophenyl)amine is dissolved in a system of solvents PEG-35 castor oil – propylene glycol dicaprylate/dicaprate with weight ratio of components of 9:1, with ratio of PS : solvent system 1:1-20 by weight, obtained solution is heated in a drying cabinet at 35-90 °C for 1.5-4.0 hours, after which amorphous magnesium aluminometasilicate is cooled to room temperature, and amorphous magnesium aluminometasilicate is sorbed on an inert porous carrier, and then a drug preparation for oral administration is obtained in the form of solid gelatinous capsules.
EFFECT: present invention provides higher pharmaceutical availability of the drug by increasing the release of N-(adamant-2-yl)-N-(para-bromophenyl)amine from the drug for oral administration into the dissolution medium.
1 cl, 2 dwg, 2 tbl, 9 ex
