METHOD FOR PREDICTION OF DURATION OF NON-METASTATIC PERIOD IN PATIENTS WITH INVASIVE BREAST CARCINOMA OF NON-SPECIFIC TYPE Russian patent published in 2025 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to oncology, and concerns methods for prediction of duration of non-metastatic period in patients with invasive breast carcinoma of non-specific type. In the method, a cell suspension obtained from freshly frozen homogenised tumour tissue is analysed by flow cytometry, in which protein markers are used to detect exclusively tumour stem cells by phenotype CD45^-pan-Cytokeratin⁺EpCAM⁺CD44⁺CD24^-N-cadherin^-, and among them – the proportion of PD-L1-positive cells. At fraction PD-Ll⁺CD45^_pan-Cytokeratin⁺EpCAM⁺CD44⁺CD24^-N-cadherin^- higher than 94.44 %, high risk of short metastatic survival rate is predicted.

EFFECT: invention increases accuracy, information content, availability and versatility of the method; method sensitivity is 80%, specificity is 83%.

1 cl, 3 ex