FIELD: biotechnologies.
SUBSTANCE: described is a method of modifying an antisense oligonucleotide (ASO) for tumour marker-dependent degradation of target mRNA by mixing four described oligonucleotides to obtain an oligonucleotide complex.
EFFECT: providing interaction of oligonucleotides with biomarker RNA inside cells.
1 cl, 4 dwg, 1 tbl, 1 ex
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