FIELD: chemistry.
SUBSTANCE: invention relates to a co-crystal of ketoprofen, lysine and gabapentin, wherein the molar ratio of components is equal to 1:1:2 and wherein the co-crystal is characterized by the following XRPD diffraction peaks: 3.6, 6.3, 18.6 and 21.7 degrees 2-theta ± 0.2 degrees 2-theta. Invention relates to a pharmaceutical composition for preventing, relieving or treating pain and/or inflammation, containing a cocrystal of the invention and at least one pharmaceutically acceptable inert filler. Invention also relates to a method of producing a cocrystal of the invention, comprising (a) suspending ketoprofen, lysine and gabapentin in a molar ratio of ketoprofen: lysine: gabapentin ranging from 1:1:2–2.5, in a suitable solvent that is methanol or ethanol; (b) dissolving ketoprofen, lysine and gabapentin, by heating the suspension and/or stirring until a clear solution is obtained; (c) further cooling the solution and (d) adding an anti-solvent such as tetrahydrofuran.
EFFECT: stable co-crystal of ketoprofen, lysine and gabapentin for preventing, relieving or treating pain and/or inflammation.
16 cl, 8 dwg, 5 tbl
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Authors
Dates
2025-06-04—Published
2021-05-04—Filed