FIELD: chemistry.
SUBSTANCE: invention relates to a co-crystal of ketoprofen, lysine and gabapentin, wherein the molar ratio of components is equal to 1:1:2 and wherein the co-crystal is characterized by the following XRPD diffraction peaks: 3.6, 6.3, 18.6 and 21.7 degrees 2-theta ± 0.2 degrees 2-theta. Invention relates to a pharmaceutical composition for preventing, relieving or treating pain and/or inflammation, containing a cocrystal of the invention and at least one pharmaceutically acceptable inert filler. Invention also relates to a method of producing a cocrystal of the invention, comprising (a) suspending ketoprofen, lysine and gabapentin in a molar ratio of ketoprofen: lysine: gabapentin ranging from 1:1:2–2.5, in a suitable solvent that is methanol or ethanol; (b) dissolving ketoprofen, lysine and gabapentin, by heating the suspension and/or stirring until a clear solution is obtained; (c) further cooling the solution and (d) adding an anti-solvent such as tetrahydrofuran.
EFFECT: stable co-crystal of ketoprofen, lysine and gabapentin for preventing, relieving or treating pain and/or inflammation.
16 cl, 8 dwg, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CO-CRYSTAL OF KETOPROFEN CONTAINING ITS COMPOSITIONS, A METHOD OF ITS PRODUCTION AND USE | 2019 |
|
RU2802975C2 |
| SYNERGISTIC MIXTURES OF GABAPENTIN AND KETOPROFEN, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USE THEREOF | 2021 |
|
RU2830013C1 |
| ANALGETIC COMPOUND AND ITS PRODUCTION METHOD | 2018 |
|
RU2791108C2 |
| NITROXY-DERIVATIVES AND THEIR SALTS, BASED ON THEM PHARMACEUTICAL COMPOSITION AND THEIR APPLICATION AS MEDICATIONS FOR CHRONIC PAIN TREATMENT | 2003 |
|
RU2340598C2 |
| CO-CRYSTALLINE FORMS OF TRAMADOL AND NSAID | 2009 |
|
RU2599717C2 |
| SALTS AND CRYSTALLINE FORMS | 2014 |
|
RU2654855C2 |
| SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USE | 2012 |
|
RU2611007C2 |
| CO-CRYSTALS OF TRANSMEMBRANE CONDUCTION REGULATOR MODULATORS IN CYSTIC FIBROSIS | 2015 |
|
RU2749213C2 |
| (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE | 2014 |
|
RU2695607C2 |
| KETAMINE PAMOATE AND USE THEREOF | 2020 |
|
RU2825336C2 |
