COCRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF IN MEDICINE Russian patent published in 2025 - IPC C07C229/26 C07C229/28 C07C59/84 A61K31/13 A61P23/00 

Abstract RU 2841250 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a co-crystal of ketoprofen, lysine and gabapentin, wherein the molar ratio of components is equal to 1:1:2 and wherein the co-crystal is characterized by the following XRPD diffraction peaks: 3.6, 6.3, 18.6 and 21.7 degrees 2-theta ± 0.2 degrees 2-theta. Invention relates to a pharmaceutical composition for preventing, relieving or treating pain and/or inflammation, containing a cocrystal of the invention and at least one pharmaceutically acceptable inert filler. Invention also relates to a method of producing a cocrystal of the invention, comprising (a) suspending ketoprofen, lysine and gabapentin in a molar ratio of ketoprofen: lysine: gabapentin ranging from 1:1:2–2.5, in a suitable solvent that is methanol or ethanol; (b) dissolving ketoprofen, lysine and gabapentin, by heating the suspension and/or stirring until a clear solution is obtained; (c) further cooling the solution and (d) adding an anti-solvent such as tetrahydrofuran.

EFFECT: stable co-crystal of ketoprofen, lysine and gabapentin for preventing, relieving or treating pain and/or inflammation.

16 cl, 8 dwg, 5 tbl

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RU 2 841 250 C1

Authors

Aramini, Andrea

Allegretti, Marcello

Bianchini, Gianluca

Lillini, Samuele

Tomassetti, Mara

Dates

2025-06-04Published

2021-05-04Filed