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1 354 709

(13)

A1

(51)

IPC

(21) (22)

Application

3963688/13, 1985-08-20

(22)

Actual filing date

1985-08-20

(45)

Published

1995-02-27

(72)

Inventor

Al'Tshtejn A.D.Andzhaparidze O.G.Antonova T.P.Baev A.A.Bendukidze K.A.Gorodetskij S.I.Zakharova L.G.Krjazhevskaja M.V.Pashvykina G.V.Fodor I.I.Chernos V.I.

RECOMBINANT PLASMID DNA PVAX2 FOR TRANSFER AND EXPRESSION OF HEPATITIS B SURFACE ANTIGEN GENE IN VARIOLOVACCINE VIRUS GENOME AND A STRAIN OF VARIOLOVACCINE VIRUS EXPRESSING THE SURFACE ANTIGEN OF HEPATITIS B VIRUS Russian patent published in 1995 - IPC

Abstract SU 1354709 A1

FIELD: biotechnology. SUBSTANCE: using plasmid pVAX2 consisting of vector pVAR15 and gene encoding hepatitis B virus surface antigen (S-gene) the latter is transferred in genome of variolovaccine virus genome - a variant of Lister-LIVP strain showing low neurovirulence for rabbit and mouse and approved at the large range in human (strain is grafted to more than 1.5 mlrd men). Prepared recombinant LIOGEN-HB/C2-ТК- induces HBsAg in infected cells and shows tk--phenotype. Thymidine kinase gene of simple virus (I) is inserted in Hind III-fragment of recombinant LIOGEN-HB/C2-tk+ for recovery of ТК--phenotype, and recombinant of LIOGEN-HB/C2-ТК+ is prepared. EFFECT: preparing of recombinant variolovaccine virus. 3 cl

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SU 1 354 709 A1

Authors

Al'Tshtejn A.D.

Andzhaparidze O.G.

Antonova T.P.

Baev A.A.

Bendukidze K.A.

Gorodetskij S.I.

Zakharova L.G.

Krjazhevskaja M.V.

Pashvykina G.V.

Fodor I.I.

Chernos V.I.

Dates

1995-02-27—Published

1985-08-20—Filed

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