FIELD: medicine. SUBSTANCE: desired product is prepared by alkylation of 2,3-dihydro-1,2,4-triazino[5,6-b] indolethion-3 with halide alkyl. The process is followed by treatment of thus obtained product with 1-morpholino-3-chlorpropanol-2. The process takes place in excess of alkali. Desired product has essential formula C16H19N5O2S, its melting point is 174 C. Toxicity of said product is 1070 mg/kg, its active dose being 20 mg/kg. EFFECT: creates novel more active compounds. 1 tbl
| Title |
Year |
Author |
Number |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| HYDROCHLORIDE OF 3-(2-DIMETHYLAMINOETHYLTHIO)-9-METHYL-1,2,4-TRIAZINO(6,5-B)INDOLE WHICH INCREASES PHYSICAL RESISTANCE |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Basieva T.S.
|
SU1061424A1 |
| 8-BROMO-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND PROLONGED STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Katkov V.F.
- Spivakova R.P.
- Krylova I.M.
- Katkova E.B.
|
SU1223608A1 |
| 3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE HYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING |
1989 |
- Tomchin A.B.
- Spivakova R.P.
- Smirnov A.V.
|
SU1623156A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| 8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING |
1991 |
- Tomchin A.B.
- Smirnov A.V.
- Gajvoronskaja V.V.
- Okovityj S.V.
- Spivakova R.P.
|
SU1809608A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE PROTECTING AGAINST ACUTE TOXIC LUNG EDEMA |
1989 |
- Tomchin A.B.
- Kropotov A.V.
- Butakov V.N.
- Urjupov O.Ju.
- Kostycheva M.V.
- Marysheva V.V.
|
SU1674533A1 |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHOXY-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Krjukova L.M.
- Zelenin K.N.
|
SU1552605A1 |
