FIELD: heterocyclic compounds, can be used in medicine. SUBSTANCE: the synthesis is effected by reacting 7-oxy-4-fluoroisoflavone with cinnamic acid chloride in pyridine on heating (1.5 hr) followed by treatment of the reaction mixture with an aqueous solution of acetic acid. The yield 75.5%, mp 212-213 C, the empirical formula: C24H15FO4. The hypotensive activity of the new compound when injected subcutaneously (100 mg/kg) is by 2 times higher than of theobromine and by 1.6 higher than that of the structural analogues by the 60th minute. EFFECT: new more active compounds of said class. 1 tbl
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Year |
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| 1-(ISOFLAVONYL-7-OXYCARBONYLVINYL)-4- (ISOFLAVONYL-7-OXYCARBONYLMETHYLENOXY) BENZENE HAVING HYPOTENSIVE AND HYPOLIPIDEMIC ACTIVITIES |
1988 |
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- Skul'Te I.V.
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- Makhmudov Ramiz Ragibovich
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- Volodarskij Leonid Borisovich
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1988 |
- Paronikjan E.G.
- Sirakanjan S.N.
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- Akopjan N.E.
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SU1540240A1 |
| PROCESS FOR PREPARING 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANIC ACID |
1990 |
- Glushkov R.G.
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- Sanzharova G.M.
- Poljakova M.Ja.
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| HYDROCHLORIDES 2-METHYL- OR 1,2-DIMETHYL-6,7 -DIMETOXY- 1,2,3,4 -TETRAHYDROIZOQUINOLINE -4-SPIRO-4 '-CYCLOHEXANOLS POSSESSING CENTRAL M-CHOLINILYTIC ACTION |
1983 |
- Agekjan A.A.
- Pirdzhanov L.Sh.
- Sarkisjan L.M.
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- Markarjan Eh.A.
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SU1104825A1 |
| 11,11-DIMETHYL-1-OXO-1,2,10,11-TETRAHYDROBENZO[h]PYRROLO-[2,1-a]-ISOQUINOLINE-2-SPIRO-2-(1-ARYL-3-AROYL-4-HYDROXY-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE MICROFLORA |
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- Aleksandrova Galina Arsent'Evna
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| METHOD OF PRODUCING 5-OXO-4,5-DIHYDRO-1H-INDENO(1,2-B)PYRIDINE A DERIVATIVES OR SULFONYL ANALOGUES THEREOF |
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- Vigante Brigita Arvidovna
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- Dubur Gunar Yanovich
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SU1198067A1 |
| ETHYL 1,6-DIARYL-4-AROYL-3-HYDROXY-2-OXO-8-PHENYL-1,7-DIAZASPIRO[4,4]NONA-3,6,8-TRIEN-9-CARBOXILATES AND METHOD OF THEIR OBTAINING |
2011 |
- Silajchev Pavel Sergeevich
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RU2467010C1 |
| 4-AMINO-6,6-DIMETHYL-5, 6-DIHYDRO-8H-PYRANO /4′,3′:4,5/ PYROLLO [2,3-D]PYRIMIDINE |
1982 |
- Noravjan A.S.
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SU1088331A1 |
