PROCESS FOR PREPARING ARALKYLAMINE DERIVATIVES OR THEIR ACID ADDITION SALTS Russian patent published in 1994 - IPC

FIELD: clinical chemistry. SUBSTANCE: process for preparing aralkylamine derivatives of the general formula I , wherein X is hydrogen, (C₁-C₄) alkoxycarbonyl; R₁ is (lower) alkyl ; R₂ is unsubstituted phenyl or which may be substituted by one substituting group, hydroxyl or (C₁-C₄) alkoxy group, or two (C₁-C₄) alkoxy groups; m is 1,2; n is 2-6; A is six-member or five-member which is unsubstituted, or optionally substituted by oxo group or hydroxyl group, or A is ring of formula II ; B is benzene ring which may have three substitutes selected from a group consisting C₁-C₄ alkoxy group, OCH₂O group or pyrrolidine group, or their acid addition salts is characterized by reacting compound of formula III , wherein Y is halogen; X is (C₁-C₄) alkoxycarbonyl; A ring is substituted by oxo group; B ring is as defined above or may be substituted by halo group, with compound of formula HN(R₁)CH₂R₂, wherein R₁ end R₂ are as defined above followed by decarboxylation, if any, or if A ring is substituted by oxo group, by reduction of it to hydroxyl with subsequent splitting off, if any, such group, and reacting with pyrrolidine, provided that B ring is substituted by halo group. EFFECT: lower toxicity and higher inhibiting capacity to choline esterase. 3 tbl