STRAIN OF HYBRID CULTURED MAMMALIAN CELLS MUS MUSCULUS L, USED FOR PREPARING OF PRECIPITATING MONOCLONAL ANTIBODIES TO HUMAN IGG Russian patent published in 1994 - IPC

Abstract RU 2010856 C1

FIELD: biotechnology. SUBSTANCE: method involves preparing of strain of hybrid cultured mammalian cells Mus musculus L. producing precipitating monoclonal antibodies to human IgG. Strain is prepared by hybridization of murine splenocytes (line Bal b/c) with myeloma cells Sp2/OAg14. Monoclonal antibodies belong to subclass IgG1, they interact with human IgG specifically and show precipitating properties. Concentration of monoclonal antibodies in cultural fluid is 5-10 micro g/ml and in ascitic fluid is 5 mg/ml. Production of antibodies continues for 30 passages in culture and for 25 passages in animals. EFFECT: preparing of strain indicated above. 1 tbl

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RU 2 010 856 C1

Authors

Knjazeva O.A.

Efetov K.A.

Tehtin S.Ju.

Troitskij G.V.

Dates

1994-04-15—Published

1992-01-09—Filed