DERIVATIVES OF THIAZOLIDINEDIONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF TREATMENT OF MAMMALIAN WITH HYPERGLYCAEMIA, A PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of thiazolidinedione of the general formula (I) where Ar - phenyl, 2-naphthyl, alkyl-substituted phenyl, alkoxy-substituted phenyl, halogen-substituted phenyl, 2-pyridinyl, methyl-substituted 2-pyridinyl, 2-quinolinyl, 2-pyridinyl, 2-benzoxazolyl, halogen-substituted 2-benzothia- -zolyl; n = 0 or 2; Ar' - phenyl, alkyl-substituted phenyl, perfluoroalkyl-substituted phenyl, halogen-substituted phenyl, alkoxy-substituted phenyl, perfluoroalkoxy-substituted phenyl or alkylthio-substituted phenyl, or their pharmaceutically acceptable salts that show antihyperglycaemic activity. Synthesized compounds can be used as agents for treatment of patients with hyperlipidemia and diabetes complications. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 22 cl, 3 tbl, 99 ex