TRIS-CARBAMIC ACID ESTERS, METHOD OF CHOLESTEROL ABSORPTION DECREASE, PHARMACEUTICAL COMPOSITION FOR CHOLESTEROL ABSORPTION DECREASE Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes compounds of the formula (I) where a substituent Z means -Ar¹,-Ar¹-Ar²,-Ar¹-O-Ar²,-Ar₁-(CH₂)_1-20-Ar₂, where substituents Ar¹ and Ar² are taken independently from a group involving phenyl, dibenzofuryl, pyridinyl and substituents Ar¹ and Ar² can be substituted independently with nitro-, C_1-20-alkyl-, C_3-8-cycloalkyl-groups; fragment A means a bridge group and p = 2. Compounds of the formula (I) inhibit cholesterol absorption from enteric tract and inhibit activity of enzymes - cholesterol ester hydrolase and acyl-CoA-cholesterol acyltransferase and therefore compounds can be used for treatment of patients with atherosclerosis, familial hypercholesterolemia, hyperlipidemia and similar diseases. EFFECT: enhanced effectiveness of the composition. 14 cl, 1 tbl, 42 ex