METHOD OF SYNTHESIS OF 2,4,6-TRIAMINO-6-PHENYLPTERIDINE Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: 2,4,6-triamino-6-phenylpteridine (1) is a drug triamteren. Synthesis is carried out by heating benzyl cyanide (2), 2,4,6-triamino-5-nitrosopyrimidine (3) and sodium hydroxide (4) at molar ratio 1:0.95:(0.25-0.5) in 8-10 m. d. butanol (5) per 1 m. d. (2) at 110-115 C for 8-12 hr followed by isolation and purification of (1). Reaction mass prepared by heating isonitrosomalononitrile guanidinium salt (6) and (4) at molar ratio (1.0-1.05):(0.25-0.5) per 1 mole (2) in 8-10 m. d. (5) at 105-115 C for 0.5-1.0 hr can be used instead components (3-5). Component (2) is added to the hot reaction mass followed by process at 110-115 C for 8-12 hr. The yield of (1) per (2) is 68-70% m. d. Content of basic substance is 99.5-100% In the case of (6) use the yield of (1) per (2) is 68-69% m. d content of basic substance is 99.3-100.1% Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 cl, 2 tbl