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2 065 498

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IPC

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Application

94045730/13, 1994-12-29

(22)

Actual filing date

1994-12-29

(45)

Published

1996-08-20

(72)

Inventor

Egorov A.Ju.Aleksandrova G.I.Rudenko L.G.Klimov A.I.Lukashok I.V.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN A/47/ SHANG-DONG /93/I(H3N2) FOR LIVING INFLUENZA INTRANASAL VACCINE FOR CHILDREN Russian patent published in 1996 - IPC

Abstract RU 2065498 C1

FIELD: virology. SUBSTANCE: vaccine strain corresponds actual virus A/Shang-dong/9/93 (H3N2) by antigenic properties. Vaccine strain A/47/Shang-dong/93/I - reassortant obtained by crossing epidemic virus A/Shang-dong/9/93 (H3N2) with cold-adopted temperature-sensitive virus A/Leningrad/134/47/57 (H2N2) - attenuation donor which is harmless for adult and children. The latter can be used for preparing reassortant vaccine strains from new epidemic viruses. Strain is deposited in State Institute of standardization and control at N 131. Strain A/47/Shang-dong/93/I multiplies actively in developing chicken embryos at optimal temperature 32-34 C and shows temperature-sensitivity and cold-adaptation. Reassortant inherited two genes from epidemic virus encoding surface proteins (hemagglutinine and neuraminidase) and six mutant genes encoding nonglycated proteins from attenuation donor. Strain A/47/Shang-dong/93/I (H3N2) is areactogenic for children of age 3-15 years at intranasal administration. EFFECT: high effectiveness of strain indicated above. 1 tbl

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RU 2 065 498 C1

Authors

Egorov A.Ju.

Aleksandrova G.I.

Rudenko L.G.

Klimov A.I.

Lukashok I.V.

Dates

1996-08-20—Published

1994-12-29—Filed

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