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2 110 277

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IPC

(21) (22)

Application

96110707/13, 1996-05-30

(22)

Actual filing date

1996-05-30

(45)

Published

1998-05-10

(72)

Inventor

Romanova Ju.R.Aleksandrova G.I.Rudenko L.G.Larionova N.V.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

FIELD: medicinal virology Russian patent published in 1998 - IPC

Abstract RU 2110277 C1

SUBSTANCE: vaccine corresponds to actual virus A/Johannesburg/33/94 (H3N2) by its antigenic properties. Vaccine strain A/47/Johannesburg/94/1 is a reassortant and obtained by breeding epidemic virus A/Johannesburg/3/94 (H3N2) with cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) as an attenuation donor. Strain is harmless for adult and children. Strain A/17/Johannesburg/94/1 is actively multiplied in developing chicken embryos at optimal temperature 32-34 C and shows temperature-sensitivity and cold-adaptability. Reassortant inherited two genes encoding surface proteins (hemagglutinin and neuraminidase) from epidemic virus and six mutant genes encoding nonglycosylated proteins from attenuation donor. Strain A/17/Johannesburg/94/1 (H3N2) is areactogenic for adult (18-20 years age) at intranasal route of administration. Vaccine strain A/17/Johannesburg/94/1 corresponds to requirements by its biological property and reactogenicity index. EFFECT: strain indicated above. 1 tbl

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RU 2 110 277 C1

Authors

Romanova Ju.R.

Aleksandrova G.I.

Rudenko L.G.

Larionova N.V.

Dates

1998-05-10—Published

1996-05-30—Filed

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