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2 078 818

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C1

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IPC

(21) (22)

Application

94037486/13, 1994-09-30

(22)

Actual filing date

1994-09-30

(45)

Published

1997-05-10

(72)

Inventor

Romanova Ju.R.Chudin A.B.Klimov A.I.Aleksandrova G.I.Rudenko L.G.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN A/17/PEKING/92/4(H3N2) FOR MAKING THE LIVE INFLUENZA INTRANASAL VACCINE FOR ADULT Russian patent published in 1997 - IPC

Abstract RU 2078818 C1

FIELD: medicinal virology. SUBSTANCE: strain is deposited in GISK at N 103. Vaccine strain A/17/Peking/92/4 - is a reassortant obtained by crossing epidemic virus A/Peking/32/92 (H3N2) with cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) that is attenuation donor that is harmless for adult and children. Strain A/17/Peking/92/4 is actively multiplicated in the developing chick embryos at optimal temperature 32-34 C. Reassortant strain inherited two genes encoding the surface proteins (hemagglutinine and neuroaminidase) from epidemic virus and six genes encoding nonglycolyzed proteins from attenuation donor. Strain A/17/Peking/92/4 (H3N2) is nonreactive for adult at age above 15 years at intranasal administration. EFFECT: enhanced effectiveness of strain indicated above. 1 tbl

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RU 2 078 818 C1

Authors

Romanova Ju.R.

Chudin A.B.

Klimov A.I.

Aleksandrova G.I.

Rudenko L.G.

Dates

1997-05-10—Published

1994-09-30—Filed

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