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2 078 819

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C1

(51)

IPC

(21) (22)

Application

94037487/13, 1994-10-30

(22)

Actual filing date

1994-10-30

(45)

Published

1997-05-10

(72)

Inventor

Egorov A.Ju.Lukashok I.V.Aleksandrova G.I.Rudenko L.G.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN B (PANAMA)90(4)E OF INFLUENZA VIRUS USED FOR PREPARING THE LIVE INTRANASAL INFLUENZA VACCINE FOR ADULT AND CHILDREN Russian patent published in 1997 - IPC

Abstract RU 2078819 C1

FIELD: medicinal virology. SUBSTANCE: vaccine strain B/Panama/90/4/E is a reassortant obtained by crossing the epidemic virus B/Panama45/90 with cold-adapted temperature-sensitive virus B/USSR/69/E as an attenuation donor that is harmless for adult and children. Strain B/Panama/90/4/E actively multiplicates in developing chicken embryos at optimal temperature 32-34 C. Reassortant inherited two genes encoding the surface proteins (hemagglutinine and neuraminidase) from epidemic virus and six genes encoding nonglycolized proteins from attenuation donor. Strain B/Panama/90/4/E is nonreactive for adult and children of age 3-15 years at intranasal administration route. Strain is deposited in GISK at N 105. EFFECT: vaccine strain indicated above. 1 tbl

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RU 2 078 819 C1

Authors

Egorov A.Ju.

Lukashok I.V.

Aleksandrova G.I.

Rudenko L.G.

Dates

1997-05-10—Published

1994-10-30—Filed

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