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2 068 271

(13)

C1

(51)

IPC

(21) (22)

Application

92006474/14, 1992-11-16

(22)

Actual filing date

1992-11-16

(45)

Published

1996-10-27

(72)

Inventor

Aleksandrova G.I.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

ATTENUATED COLD-ADAPTED STRAIN OF INFLUENZA VIRUS B/LENINGRAD/14/17/55 FOR LIVING INFLUENZA VACCINE STRAIN PREPARING Russian patent published in 1996 - IPC

Abstract RU 2068271 C1

FIELD: virology, medicine. SUBSTANCE: vaccine strain B/Leningrad/14/17/55 is obtained by carrying out 17 passages of virus B/Leningrad/14/55 in developing chicken embryos at 23 C that results to temperature-sensitivity and cold-adaptation properties. Strain of virus B/Leningrad/14/17/55 shows the following properties: hemagglutinating activity: 1:84-1:236, infection activity - 6.0-7.0 lg ЭИД 30/0.2 ml (infectious embryo doses); vs marker - 4.0-5.0 lg, i. e. strain is temperature-sensitive one (vs-); on marker lg ЭИД 50/0.2 ml, 4.0-5.0 lg. Strain shows genetic stability and shows areactogenic immunogenicity for adult and children. EFFECT: influenza virus strain indicated above.

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RU 2 068 271 C1

Authors

Aleksandrova G.I.

Dates

1996-10-27—Published

1992-11-16—Filed

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