METHOD OF INSULIN DERIVATIVES PREPARING Russian patent published in 1997 - IPC

FIELD: medicine, endocrinology, biochemistry. SUBSTANCE: method involves interaction of insulin with proteinase protein inhibitors in an aqueous solution in the presence of cross-linking agent. Ovomucoid from duck egg protein is used as protein inhibitors of proteinases. Activity of the obtained insulin derivatives at oral administration equals practically to that of parent insulin activity at its subcutaneous administration. Insulin derivatives can be used for treatment of patients with diabetes mellitus. EFFECT: improved method of preparing. 1 tbl