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2 084 524

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C1

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IPC

(21) (22)

Application

94037485/13, 1994-09-30

(22)

Actual filing date

1994-09-30

(45)

Published

1997-07-20

(72)

Inventor

Romanova Ju.R.Chudin A.B.Klimov A.I.Rudenko L.G.Aleksandrova G.I.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Ramn

STRAIN A/17/TEXAS/91/1/3 (H1N1) FOR PRODUCTION OF LIVE INTRANASAL ANTIINFLUENZA VACCINE FOR ADULTS Russian patent published in 1997 - IPC

Abstract RU 2084524 C1

FIELD: medicinal virology. SUBSTANCE: vaccine strain A/17 Texas/91/1/3 (H1N1) is obtained by method of genetic reassortation of epidemic virus A/Texas/36/91 (H1N1) with cold-adapted strain A/Leningrad/134/17 (H2N2) - attenuation donor followed by selection in the presence of antiserum to virus A/Leningrad/134/17/57 (H2N2). Infectious activity at reproduction in developing embryos at 32 C for 48 h - 7.0 lg EID 50/0.2 ml, hemagglutinating activity = 1:256. EFFECT: strain indicated above, enhanced effectiveness of vaccine. 1 tbl

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RU 2 084 524 C1

Authors

Romanova Ju.R.

Chudin A.B.

Klimov A.I.

Rudenko L.G.

Aleksandrova G.I.

Dates

1997-07-20—Published

1994-09-30—Filed

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