FIELD: organic chemistry. SUBSTANCE: product: 5-[4'-[2-butyl-4-chloro-5-(3-methyl-1,2,4-oxaziazole-5-yl) -1-imidazolylmethylbiphenyl-2-yl] ]-triphenylmethyl-1H-tetrazole, empirical formula is C43H37N8ClO, yield is 43%, m. p. is 175-177 C. Analysis: thin-layer chromatography in solvent toluene:ethyl acetate, 10:1; value Rf = 0.4. Synthesized compounds were used in medicine for hypertension and cardiac-vascular diseases treatment. EFFECT: improved method of synthesis. 7 cl, 3 dwg
| Title |
Year |
Author |
Number |
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1992 |
- Diter Binder[At]
- Jozef Vajnberger[At]
|
RU2105764C1 |
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0 |
- Diter Binder
- Frants Rovenski
- Khubert Peter Ferber
|
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0 |
- Diter Binder
- Frants Rovenstski
|
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2004 |
- Almirante Nikoletta
- Del' Soldato P'Ero
- Ongini Ehnnio
|
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2008 |
- Allegretti Pol
- Choi Seok-Ki
- Gendron Roland
- Fazeri Pol R.
- Dzhendza Kit
- Makkinnell Robert Mjurrej
- Makmertri Darren
- Olson Bruk
|
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| BIPHENYL DERIVATIVES AND METHOD OF PREPARING THEREOF |
1993 |
- Khiroaki Janagisava[Jp]
- Esija Amemija[Jp]
- Takuro Kanazaki[Jp]
- Jasuo Simodzi[Jp]
- Khirojuki Kojke[Jp]
- Tosio Sada[Jp]
|
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1992 |
- P'Er Perro[Fr]
- Klod Mjuno[Fr]
- Ivett Mjuno[Fr]
|
RU2107062C1 |
| TETRASUBSTITUTED DERIVATIVES OF IMIDAZOLE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION |
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- Alan Korb'E
- P'Er Depre
- Mishel' Fortehn
- Zhak Gijom
- Bertran Ehkman
|
RU2174513C2 |
| DERIVATIVES OF THIENYLHYDROXYALKYLAMINE OR THEIR PHARMACEUTICALLY COMPATIBLE ACID ADDITIVE SALTS |
1990 |
- Diter Binder[At]
- Gerkhard Grajer[At]
- Frants Rovenski[At]
- Fridrikh Khillebrand[At]
|
RU2027716C1 |
| ARALKYLSUBSTITUTED IMIDAZOLES SHOWING ANTIHYPERTENSIVE ACTION, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITING ACTIVITY WITH RESPECT TO ANGIOTENSIN II |
1990 |
- Robert Dzhon Ardeki[Us]
- Dejvid Dzhon Karini[Us]
- Dzhon Dzhounes Vyjtatutas Danchija[Us]
- Pankras Khor-Bun Vong[Us]
|
RU2067581C1 |
